Fenben is an anthelmintic drug commonly used in veterinary medicine to treat parasitic worms like whipworms, hookworms and one species of tapeworm. It has also been shown to have anticancer effects in human cancer cells.
This is because fenben works by blocking tubulin, a protein that builds up the transport ways within metabolically active cells. This results in cell-cycle arrest and apoptosis exclusively in actively growing cancer cells.
How does Fenben work?
Fenben is a broad-spectrum benzimidazole carbamate dewormer that has been in use as an anthelmintic for about six decades. It belongs to a class of drugs called the benzimidazole family (which I have coined BZ) and along with albendazole and mebendazole, is one of the most effective anthelmintic treatments available.
Recent studies have shown that fenbendazole has potent antitumor activity in human lung cancer cells. The drug appears to work through a combination of moderate microtubule disruption, p53 stabilization, and interference with glucose metabolism, leading to preferential elimination of tumor cells in both vitro and in vivo models.
In an animal model, fenbendazole significantly reduced tumor growth when administered to mice with a KRAS mutation. These results suggest that fenbendazole may be able to overcome drug resistance in cancer therapy.
What are the side effects of Fenben?
Fenbendazole is an antiparasitic drug used to treat parasitic worm infections in dogs, cats, goats, sheep, cattle, horses, and other mammals. It is also used to treat a variety of veterinary infections, including giardiasis and hookworms. It is not recommended for use in humans because it can be toxic to the liver.
Studies have shown that fenbendazole can interfere with the formation of microtubules, a protein scaffolding that helps cells establish shape and movement. These structures are crucial for transporting organelles and cargo throughout the cell, and are essential in the cellular response to disease. Fenbendazole may be able to inhibit cancer cell proliferation by disrupting the microtubule network, leading to apoptosis or cell death.
In a recent study, researchers found that fenbendazole can reactivate the p53 gene inside the genome, which functions as a tumor suppressor. This gene is often inactivated by genetic mutations, which can lead to the development of cancer. The authors of the study suggest that fenbendazole could be a new treatment for a variety of cancers by targeting multiple molecular pathways simultaneously.
Another research suggests that fenbendazole may have anti-tumor effects in mice. The authors of the study report that when 1 mg/mouse of fenbendazole was administered orally every 2 days for 12 days, it resulted in reduced tumor size and weight. The drug was also able to block the expression of RAS-related signaling pathways in human lung cancer cells with a KRAS mutation.
What are the risks of Fenben?
As with any medication there are risks involved in taking Fenben. Those risks are mostly related to interactions with other medications that you may be taking. It is also possible to overdose on Fenben if you take too much of it. You should talk to your doctor before starting any new medication or supplement.
Fenbendazole is a broad-spectrum anthelmintic in the benzimidazole family of drugs(I coined it Benz) and has been safely used for decades as a dewormer to treat parasites and worms in animals (common brand names include Pancur). It works by inhibiting the enzymes that produce certain important amino acids, which prevents these amino acids from entering the cell.
A man named Joe Tippens claims to have cured himself of cancer using a cheap dog deworming drug called Fenbendazole. He took it along with turmeric and other supplements and says he was able to beat his glioblastoma in 12 weeks.
Researchers have found that fenbendazole kills cancer cells by interfering with their glucose metabolism. They also discovered that fenbendazole blocks the protein kinase PAK1, which is involved in the control of cell growth. This discovery shows that fenbendazole can be a powerful addition to existing chemotherapies. Researchers are now looking for ways to combine it with other treatments to improve their effectiveness. Eventually, they hope to develop a drug that is purpose-made to fight cancer.
What are the benefits of Fenben?
Fenbendazole is a broad-spectrum benzimidazole carbamate anthelmintic that has been in clinical use for nearly 50 years. It is effective against the genus Ascaris, hookworms, whipworms, and the tapeworm genus Taenia (except Dipylidium caninum). It also has potent anti-cancer activity in laboratory studies. Dr Doug has been using it in horses, dogs and cats for over 30 years. He is now combining it with curcumin in his Turmeric Pet & Dog Bites product. It’s now available on his website. fenben for humans